Written by 1:45 am OTC Medications

Should I Try Melatonin for Insomnia?

“Dear Honest Apothecary,

I have a hard time falling asleep at night.  My friend suggested melatonin.  Should I try it?”

I’m glad you asked.

A lot of attention has been given lately to melatonin, a naturally occurring hormone produced by the pea-sized pineal gland in the brain.  I’ve seen it for sale everywhere from grocery stores to convenience stores, from online shops to the pharmacy shelves.  It comes in a wide range of dosages and is made by dozens of different manufacturers.  It also comes in many different dosage forms such as liquid, capsules, tablets and rapidly dissolving pills.  It even comes in a topically applied “sleep cream.”  Melatonin is everywhere.

And it isn’t just the OTC shelves where you find it.  In some other countries, melatonin is available only by prescriptions.  Several years ago in the U.S. (about 10 to be exact) the FDA approved Rozerem (ramelteon), a prescription-only analogue of melatonin indicated to help treat insomnia.  By most standards it was a financial flop for the manufacturer Takeda.  That doesn’t mean the drug is useless, but possibly just that they needed a better marketing strategy.  More recently the FDA approved Hetlioz (tasimelteon), a 20mg capsule taken at bedtime to treat non-24 hour disorder, a sleep disorder frequently experienced by the blind.  Tasimelteon, like ramelteon, is a melatonin-receptor agonist, meaning it will stimulate the same receptors in the brain as melatonin.

NOTE:  This article is just about OTC melatonin and its use for insomnia.  It is NOT an article intended to discuss all the possible causes of insomnia or when you should seek medical attention for insomnia.  Suffice it to say that chronic problems with sleeping should be evaluated by a physician.  This article is not intended to eliminate that approach.


Scientists aren’t entirely sure how melatonin works.  That’s not to say we don’t have a good working knowledge of the biochemistry of melatonin and the receptors that are stimulated.  We have identified receptors in the brain and other parts of the body which are triggered by melatonin.  We cleverly call them M1 and M2 receptors.  Stimulation of these receptors in the brain seems to be associated with sleep onset. 

Under normal conditions the light/dark cycle helps control our natural release of this hormone in the brain from the pineal gland.  When it gets dark, particularly in the absence of certain wavelengths of light, melatonin is produced.  For that reason, melatonin is sometimes referred to as the “Vampire Hormone” because it only comes out at night.  But what exactly happens that causes us to get sleepy isn’t totally clear.

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The simple answer to this question is YES…for some people and to some degree.  Melatonin helps improve sleep onset (the time it takes to initially fall asleep).  It’s not as potent as some other sedatives, but it also isn’t habit forming.

Here’s the truth:  If you want to find studies showing that melatonin does NOT work to help treat insomnia…you can find them.  If you want to find studies showing that melatonin DOES work to treat insomnia…you can find them too.  What does that tell us?  Not a lot.  But it is fair to say that it works for some people, and further research may be needed to help identify the right patient or right condition for which it works best.

There are, however, a few problems with OTC melatonin supplements.  The first problem is that melatonin supplements aren’t exclusively working on the M-receptors in the brain.  We have other M-receptors and those will be stimulated by melatonin as well.  This may or may not be significant. The prescription ramelteon has a much higher affinity for the brain M-receptors than other M-receptors.  Also, melatonin doesn’t last very long.  We refer to that as having a short “half life.”  That just means that the effects wear off pretty quickly.  The prescription version does tend to last longer.

A final problem with the OTC melatonin supplements are lack of consistency in product quality.  Are you getting a good product?  Does it really have the amount of melatonin it says on the label?  It is hard to be sure.

Those things being said – melatonin supplements do work for many people and I’m reasonably comfortable recommending it to patients.

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Some people have expressed concern over the fact that melatonin is a “hormone” and that supplementing with hormones could be dangerous.  Others have expressed worries about drug interactions with melatonin.   Still others worry about side effects.  Allow me to briefly address these.

Hormones – Melatonin is a hormone.  But there are all sorts of types of hormones that our body makes and which we consume safely.  Melatonin is in a different class of hormones than estrogen or testosterone.  Our body makes melatonin from an amino acid which is also in many foods we consume.

Drug Interactions – Melatonin may interact with other medications, and in certain circumstances should not be used (or used with more caution and possibly a lower dose).  For example, fluvoxamine (an antidepressant) carries a contraindication (meaning DO NOT USE IT) for concomitant use with ramelteon (a melatonin analogue).  Thus, I wouldn’t recommend using them together.  Oral contraceptives increase melatonin secretion, therefore I wouldn’t use anything but the lowest doses of melatonin in that case.  I wouldn’t recommend using melatonin in patients on blood thinners (like warfarin) or immune suppressants.  Don’t mix melatonin with other drugs that tend to cause sedation like alcohol or other sleeping aids.  Patients should be aware that some medications used to treat high blood pressure may actually lower our natural melatonin levels (like beta blockers or calcium channel blockers).

Side Effects – I tell diabetics to keep a closer watch on their blood sugar when starting melatonin, as it may cause an increase or decrease in blood sugar levels.  It may cause drowsiness – so be aware of that.  I don’t recommend it for pregnant women or those trying to become pregnant.



There is no recommended “daily” dose of melatonin.  For insomnia I typically recommend 1mg taken 30 minutes prior to bedtime.  I have found this dosage to be effective for many of my patients I have spoken to.  Other patients find they need 3mg.

©Jason Poquette and The Honest Apothecary.  Unauthorized use and/or duplication of this material without express and written permission from this blog’s author and/or owner is strictly prohibited. Excerpts, quotes and links may be used, provided that full and clear credit is given to Jason Poquette and The Honest Apothecary with appropriate and specific links to the original content. 





Last modified: April 17, 2023